| Product information | Protocols | References | Technical support | Reviews |
Product overview
| Product name | 3-Hydroxyanthranilic acid antibody |
| Synonyms | Anti-3-Hydroxy-Anthranilic acid antibody 2-Amino-3-hydroxybenzoic acid antibody 3-OH-Anthranilic acid antibody 3-hydroxanthranilate antibody 3-OHAA antibody |
| Immunogen | Conjugated 3-Hydroxyanthranilic acid |
| Isotype | IgG1 k chain |
| Clone | Clone 5B2-G2 |
| Specificity | When tested in competitive ELISA, the anti- 3-HydroxyAnthranilic acid antibody did not show any significant cross reactivity with Anthranilic acid or Cinnabarinic acid conjugates |
| Lot number | 140201 |
| Expiration date | April 2022 |
Storage
| Form | Liquid |
| Purity | Purified IgG |
| Concentration | 0,5 mg/ml |
| Storage | Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles. |
| Material safety datasheet | Download MSDS |
Protocols
| Immunohistochemistry (IHC) | Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
| Immunofluorescence (IF) | Dilute at 1:100-1:1000 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate with fluorescent dyes conjugated secondary antibody |
| Comments | Optimal working dilutions must be determined by the end-user |
| Restrictions | For research use only |
References
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Selected publications on 3-HydroxyAnthranilic acid:
- Lee WS, Lee SM, Kim MK, Park SG, Choi IW, Choi I, Joo YD, Park SJ, Kang SW, Seo SK. Int Immunopharmacol. The tryptophan metabolite 3-hydroxyanthranilic acid suppresses T cell responses by inhibiting dendritic cell activation. 2013 Nov;17(3):721-6. doi: 10.1016/j.intimp.2013.08.018. Epub 2013 Sep 9.
- Adams S, Braidy N, Bessede A, Brew BJ, Grant R, Teo C, Guillemin GJ. The kynurenine pathway in brain tumor pathogenesis. Cancer Res. 2012 Nov 15;72(22):5649-57. doi: 10.1158/0008-5472.CAN-12-0549. Epub 2012 Nov 9.
- Krause D, Suh HS, Tarassishin L, Cui QL, Durafourt BA, Choi N, Bauman A, Cosenza-Nashat M, Antel JP, Zhao ML, Lee SC. The tryptophan metabolite 3-hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1. Am J Pathol. 2011 Sep;179(3):1360-72. doi: 10.1016/j.ajpath.2011.05.048.
- Yan Y, Zhang GX, Gran B, Fallarino F, Yu S, Li H, Cullimore ML, Rostami A, Xu H. IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis. J Immunol. 2010 Nov 15;185(10):5953-61. doi: 10.4049/jimmunol.1001628. Epub 2010 Oct 13.
- Hayashi T, Mo JH, Gong X, Rossetto C, Jang A, Beck L, Elliott GI, Kufareva I, Abagyan R, Broide DH, Lee J, Raz E. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18619-24. Epub 2007 Nov 14.
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